Keiko Kobayashi Selected Research

Citrulline

10/2012	Neonatal intrahepatic cholestasis caused by citrin deficiency: prevalence and SLC25A13 mutations among Thai infants.
12/2010	Neonatal intrahepatic cholestasis associated with citrin deficiency (NICCD): a case series of 11 Malaysian patients.
11/2010	[Therapeutic approaches for patients with adult-onset type II citrullinemia (CTLN2): effectiveness of treatment with low-carbohydrate diet and sodium pyruvate].
9/2009	[A case of adult-onset type II citrullinemia with repeated nonconvulsive status epilepticus].
3/2008	Evidence of cataplerosis in a patient with neonatal classical galactosemia presenting as citrin deficiency.
12/2007	Six cases of citrin deficiency in Korea.
3/2007	Citrin deficiency: a novel cause of failure to thrive that responds to a high-protein, low-carbohydrate diet.
10/2005	Metabolic derangements in deficiency of citrin, a liver-type mitochondrial aspartate-glutamate carrier.
10/2004	Effects of citrin deficiency in the perinatal period: feasibility of newborn mass screening for citrin deficiency.
4/2004	Feasibility of auxiliary partial orthotopic liver transplantation from living donors for patients with adult-onset type II citrullinemia.

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Keiko Kobayashi Research Topics

Disease

35	Citrullinemia 01/2013 - 01/2002
28	Neonatal-onset citrullinemia type 2 01/2013 - 01/2002
24	Adult-onset citrullinemia type 2 01/2017 - 01/2002
13	Hyperammonemia 12/2011 - 11/2002
9	Intrahepatic Cholestasis 11/2012 - 05/2003
9	Fatty Liver 03/2011 - 09/2002
6	Necrosis 01/2016 - 01/2010
5	Neoplasms (Cancer) 04/2022 - 04/2004
5	Gas Gangrene (Gangrene, Gas) 10/2020 - 09/2012
5	Brain Diseases (Brain Disorder) 11/2010 - 03/2005
5	Cholestasis 04/2010 - 03/2005
5	Galactosemias (Galactosemia) 08/2009 - 10/2005
4	Hepatitis 01/2012 - 01/2008
4	Cardiomegaly (Heart Hypertrophy) 03/2011 - 09/2002
4	Neonatal hemochromatosis 01/2005 - 01/2002
3	Enterotoxemia 08/2023 - 11/2016
3	Atherosclerosis 01/2016 - 01/2013
3	Liver Diseases (Liver Disease) 04/2010 - 02/2006
3	Type 2 Diabetes Mellitus (MODY) 01/2009 - 01/2008
3	Hypoglycemia (Reactive Hypoglycemia) 08/2007 - 12/2002
3	Jaundice (Icterus) 04/2006 - 11/2002
2	Inflammation (Inflammations) 01/2019 - 01/2015
2	Cognitive Dysfunction 01/2019 - 01/2019
2	Infections 01/2016 - 04/2005
2	Non-alcoholic Fatty Liver Disease 01/2016 - 11/2008
2	Alzheimer Disease (Alzheimer's Disease) 01/2016 - 01/2013
2	Body Weight (Weight, Body) 11/2012 - 06/2009
2	Failure to Thrive 12/2010 - 03/2007
2	Hepatic Encephalopathy 01/2010 - 04/2004
2	Metabolic Diseases (Metabolic Disease) 08/2009 - 06/2007
2	Acute Liver Failure (Fulminant Hepatic Failure) 06/2009 - 11/2004
2	Hypertrophy 01/2009 - 02/2006
2	Proteinuria 01/2008 - 01/2007
2	Hepatocellular Carcinoma (Hepatoma) 12/2007 - 10/2003
2	Brain Edema (Cerebral Edema) 02/2006 - 03/2005
2	Hypoproteinemia 10/2005 - 11/2004
2	Coma (Comas) 10/2005 - 01/2002
1	Sclerosis 10/2023
1	Rheumatic Diseases (Rheumatism) 10/2023
1	Ventilator-Associated Pneumonia 01/2023

Drug/Important Bio-Agent (IBA)

32	citrinIBA 01/2017 - 01/2002
15	aspartate-glutamate carrierIBA 01/2013 - 01/2002
13	Proteins (Proteins, Gene)FDA Link 04/2022 - 05/2003
13	CitrullineIBA 10/2012 - 01/2002
11	DNA (Deoxyribonucleic Acid)IBA 01/2013 - 01/2002
11	Urea (Carbamide)FDA LinkGeneric 11/2010 - 12/2002
9	EnzymesIBA 01/2016 - 12/2002
8	AmmoniaIBA 11/2010 - 01/2002
7	Carnitine (L-Carnitine)FDA LinkGeneric 03/2011 - 09/2002
6	CarbohydratesIBA 11/2012 - 05/2003
6	Argininosuccinate Synthase (Argininosuccinate Synthetase)IBA 10/2005 - 12/2002
5	Glycerol (Glycerine)FDA LinkGeneric 01/2017 - 01/2002
5	Protein Isoforms (Isoforms)IBA 01/2013 - 01/2002
5	Pyruvic Acid (Pyruvate)IBA 11/2012 - 08/2007
5	Alanine Transaminase (SGPT)IBA 10/2012 - 06/2009
5	Messenger RNA (mRNA)IBA 03/2011 - 09/2002
5	Methionine (L-Methionine)FDA Link 12/2007 - 05/2003
4	Virulence Factors (Pathogenicity Factors)IBA 10/2020 - 09/2012
4	Amino Acids FDA Link 11/2012 - 05/2003
4	SodiumIBA 11/2012 - 01/2010
4	Bile Acids and Salts (Bile Acids)IBA 10/2012 - 10/2004
4	Aspartate Aminotransferases (Aspartate Transaminase)IBA 10/2012 - 06/2009
4	Threonine (L-Threonine)FDA Link 10/2012 - 10/2005
4	Galactose (Galactopyranose)FDA LinkGeneric 08/2009 - 05/2003
3	Fatty Acids (Saturated Fatty Acids)IBA 02/2021 - 08/2006
3	Sucrose (Saccharose)IBA 01/2017 - 08/2007
3	CeramidesIBA 01/2016 - 06/2009
3	Glycerolphosphate Dehydrogenase (Glycerol 3 Phosphate Dehydrogenase)IBA 11/2012 - 08/2007
3	Therapeutic UsesIBA 12/2011 - 04/2004
3	Arginine (L-Arginine)FDA Link 11/2010 - 11/2002
3	NAD (NADH)IBA 08/2007 - 12/2002
2	Clostridium perfringens epsilon-toxinIBA 08/2023 - 11/2016
2	Toll-Like Receptor 4IBA 01/2021 - 01/2017
2	CytokinesIBA 01/2019 - 01/2015
2	Clostridium perfringens delta-toxin (CPDT)IBA 02/2018 - 01/2016
2	Type C PhospholipasesIBA 01/2015 - 05/2013
2	oxidized low density lipoproteinIBA 10/2014 - 01/2009
2	Clostridium perfringens alpha toxinIBA 05/2013 - 09/2012
2	Complementary DNA (cDNA)IBA 01/2013 - 04/2004
2	Triglycerides (Triacylglycerol)IBA 11/2012 - 02/2006
2	Glucose (Dextrose)FDA LinkGeneric 10/2012 - 03/2011
2	OrnithineIBA 08/2009 - 12/2002
2	Insulin (Novolin)FDA Link 07/2008 - 01/2008
2	Lactic Acid (Lactate)FDA LinkGeneric 08/2007 - 04/2006
2	Mannitol (Osmitrol)FDA LinkGeneric 02/2006 - 03/2005
2	Systemic carnitine deficiencyIBA 02/2006 - 12/2002
2	Aspartic Acid (Aspartate)FDA Link 04/2004 - 01/2002
2	malic acid (malate)IBA 04/2004 - 01/2002
2	Solute Carrier ProteinsIBA 12/2002 - 01/2002
1	Mycophenolic Acid (Cellcept)FDA LinkGeneric 10/2023
1	Oxygen (Dioxygen)IBA 04/2022
1	Doxorubicin (Adriamycin)FDA LinkGeneric 04/2022

Therapy/Procedure

14	Therapeutics 01/2019 - 01/2002
8	Liver Transplantation 12/2010 - 01/2002
3	Protein-Restricted Diet (Diet, Protein Restricted) 01/2010 - 11/2002
2	Palliative Care (Palliative Therapy) 11/2015 - 10/2003
2	Oral Administration 12/2011 - 06/2009
2	Carbohydrate-Restricted Diet (Low Carbohydrate Diet) 11/2010 - 05/2003
2	High-Protein Low-Carbohydrate Diet (Atkins Diet) 03/2007 - 05/2003
1	Induced Hypothermia 01/2023